Amphetamine induced endogenous opioid release in the human brain detected with [¹¹C]carfentanil PET: replication in an independent cohort.
نویسندگان
چکیده
This study aimed to replicate a previous study which showed that endogenous opioid release, following an oral dose of amphetamine, can be detected in the living human brain using [11C]carfentanil positron emission tomography (PET) imaging. Nine healthy volunteers underwent two [11C]carfentanil PET scans, one before and one 3 h following oral amphetamine administration (0.5 mg/kg). Regional changes in [11C]carfentanil BPND from pre- to post-amphetamine were assessed. The amphetamine challenge led to significant reductions in [11C]carfentanil BPND in the putamen, thalamus, frontal lobe, nucleus accumbens, anterior cingulate, cerebellum and insula cortices, replicating our earlier findings. None of the participants experienced significant euphoria/'high', supporting the use of oral amphetamine to characterize in vivo endogenous opioid release following a pharmacological challenge. [11C]carfentanil PET is able to detect changes in binding following an oral amphetamine challenge that reflects endogenous opioid release and is suitable to characterize the opioid system in neuropsychiatric disorders.
منابع مشابه
Amphetamine induced endogenous opioid release in the human brain detected with [11C]carfentanil PET: Replication in an independent cohort
Complete List of Authors: Mick, Inge; Imperial College, Myers, Jim; Imperial College, Stokes, Paul; King's College, ; Imperial College, Erritzoe, David; Imperial College, Colasanti, Alessandro; Imperial College, ; King's College, ; Imanova Ltd., Bowden-Jones, Henrietta; National Problem Gambling Clinic, Clark, Luke; University of Cambridge, Gunn, Roger; Imperial College, ; Imanova Ltd., Rabiner...
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ورودعنوان ژورنال:
- The international journal of neuropsychopharmacology
دوره 17 12 شماره
صفحات -
تاریخ انتشار 2014